تایپینگ کپسولی استرپتوکوکهای گروه B جدا شده از زنان باردار در شهر بوشهر
نویسندگان: Saied Ghayour, Eskandar Hoseinnezhad-Lazarjani, Somayyeh Gharibi, Mohammad Ali Haghighi, Maliheh Shokouhfard, Mahnaz Gholipour-Shahraki ©
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خلاصه مقاله: Background: Group B Streptococcus (GBS) or Streptococcus agalactiae has been described as one of the leading causes of invasive infections in newborns and pregnant women. There are ten GBS serotypes described Ia, Ib, II to IX on the basis of capsular polysaccharide (CPS) variations which is closely related to bacterial virulence. Understanding the serotype distribution in a specific population facilitates the development of effective vaccines and appropriate antibiotic prescriptions. This study aimed to evaluate the serotype distribution of GBS using the multiplex PCR among pregnant women in Bushehr city.
Material and Methods: In this study, the DNA of 16 GBS clinical samples isolated from pregnant women were extracted by a commercial kit. Capsular types were determined by Multiplex PCR to identify Ib, II-V serotypes.
Results: The most common CPS types were III (37.5%), II (31.25%), V (18.75%), Ib, and IV (6.25%) respectively.
Conclusion: Results represent that the CPS III was the most dominant type followed by CPS II and V, respectively. CPS III causing a higher rate of disease among neonates and CPS II has a considerable prevalence in maternal and newborn infections worldwide. CPS II has been reported as the predominant serotype in Thai-Myanmar, Catalonia, and Gambia. Recently, a close genetic relationship between the strains of CPS V and its recovery has been noted. In addition, recent studies observed the circulation of CPS IV worldwide, which is considered as an important cause of both neonatal and adult infections. The prevalence of serotypes III, II, and V in Bushehr should be considered as a warning for the increase of GBS-related diseases. This pattern can be the result of various factors such as population genetics and community health programs. Considering the results, appropriate antibiotic prescription along with related public health education seems to be necessary.
Key Words: GBS, Capsular Typing, Multiplex PCR, Streptococcus agalactiae
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