بررسی مقایسه ای توکسوکاریازیس در بیماران مبتلا به پارکینسون و افراد سالم با استفاده از روش سرولوژی

Fattaneh Mikaeili ©, Amir Masoud Salemi, Mohammad Saleh Bahreini, Seyed Hamed Taghavifard, Qasem Asgari

بررسی مقایسه ای توکسوکاریازیس در بیماران مبتلا به پارکینسون و افراد سالم با استفاده از روش سرولوژی

کد: G-85420

نویسندگان: Fattaneh Mikaeili ©, Amir Masoud Salemi, Mohammad Saleh Bahreini, Seyed Hamed Taghavifard, Qasem Asgari

زمان بندی: زمان بندی نشده!

برچسب: ویرایش شده

دانلود: دانلود پوستر

خلاصه مقاله: Introduction: Human toxocariasis is caused by Toxocara canis and Toxocara cati, the parasitic roundworms in the intestine of dogs and cats, respectively. Since the association between Parkinson and toxocariasis is controversial, and some studies have suggested possible changes in neurotransmitter levels such as GABA, dopamine, serotonin, and monoamines in Toxocara-infected animals, the aim of this study was to investigate the seroprevalence of Toxocara infection among patients with Parkinson in comparison with healthy persons. Methods: This case-control study was conducted on 120 blood samples from patients with Parkinson and 120 healthy persons in Shiraz city, southern Iran. The serum samples were evaluated for the detection of IgG anti-Toxocara antibodies by ELISA using the excretory-secretory (E/S) antigens prepared from the T. canis second stage larvae. A structured questionnaire was completed by participants to obtain sociodemographic data such as gender and age. Statistical analysis was performed using SPSS software version 18 (SPSS, Chicago, IL, USA). The study was approved by the research ethics committee of Shiraz University of Medical Sciences (ethical code: IR.SUMS.MED.REC.1398.491). Results: The patients with Parkinson were 34 females (28.3%) and 86 males (71.7%) with the mean age of 63.21±10.424 years. The healthy persons (n=120) included 35 females (29.2%) and 85 males (70.8%) with the mean age of 63.99±8.534 years. The seroprevalence of toxocariasis in patients with Parkinson was higher than the healthy persons with no significant difference in Toxocara seropositivity between two groups (14.2% vs 13.3%, P = 0.854). The association between Toxocara infection and variables such as gender (P = 0.298) and age (P = 0.115) were not statistically significant. Conclusion: This study indicates that there was no significant difference in Toxocara seropositivity between the control group and patients with Parkinson. Further study on different regions such as urban and rural areas with a large sample size and using questionnaire for considering risk factors of Parkinson and toxocariasis is recommended. Keywords: Seroprevalence, Toxocara, Parkinson, Shiraz, Iran.

دیدگاه ها (0)

تاکنون دیدگاهی منتشر نشده است. شما اولین نفر باشید!

ارسال یک دیدگاه

ارسال دیدگاه توسط مدیریت بسته شده است.