بررسی شیوع و الگوی حساسیت آنتی¬بیوتیکی سویه¬های کلبسیلا پنومونیه جدا شده از نمونه¬های بالینی بیماران بستری در بیمارستان¬های شهر اصفهان
نویسندگان: مریم محمدیاری باولکی, دکتر داریوش شکری ©, دکتر سید مهدی قاسمی, دکتر آرمان رستم زاد
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خلاصه مقاله: Abstract
Objective: Klebsiella pneumoniae is a gram-negative bacterium that plays an important role in nosocomial infections. Antimicrobial resistance to bacterial pathogens is a challenge whose persistence is associated with an increased risk of treatment failure and recurrent infections. It is also an important factor in increasing mortality and consequently increasing health care costs. Accordingly, the World Health Organization named 2011 the Year of Antibiotic Resistance. The aim of this study was to determine the pattern of susceptibility and antibiotic resistance of Klebsiella pneumoniae isolated from patients in Isfahan hospitals.
Method: This cross-sectional descriptive study was performed to evaluate the frequency of antibiotic resistance of Klebsiella pneumoniae in 2020 and 2021. After Klebsiella pneumoniae was identified by bacteriological and biochemical tests, antibiotic susceptibility testing was performed by disk diffusion method. Ceftazidime, cefotaxime, ceftriaxone, cefoxitin, ciprofloxacin, amikacin, gentamicin, colistin, imipenem, doripenem, ortapenem, and meropenem were used to determine bacterial susceptibility. The results were read in accordance with the CLSI 2020 guidelines. SPSS v26 software was used for data analysis.
Results: In this study, from a total of 291 clinical specimens, 49 bacteria of Klebsiella pneumoniae were isolated and identified. 36.7% of the samples were from female patients and 63.3% from male patients. In this study, 17 isolates (34.7%) were related to urine samples and 32 isolates (65.3%) were related to different samples (urine, blood, sputum, ascites, tissue secretions and wounds). According to the results, colistine (89.8%) and amikacin (61.2%) had the highest sensitivity and the highest resistance to cefotaxime (75.5%), doripenem (63.3%) and ceftriaxone (71.4%).
Conclusion: According to results, the most effective drug for the treatment of Klebsiella pneumoniae is colistin and amikacin. The isolates of klebsiella pneumoniae with high invasive power, in patients hospitalized in special wards are able to cause hospital infections. Therefore, it seems necessary to determine the antibiotic resistance pattern in order to select the appropriate treatment for the infections caused by such a bacterium.
Keywords: Klebsiella pneumoniae, Nosocomial infection, Antibiotic resistance
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