بررسی فوزاریوزیس در بیماران مبتلا به کوید-19 در ایران و بررسی مروری آن در جهان
نویسندگان: Mohammad T. Hedayatia ©, Mona Ghazanfari, Amir Arastehfar, Lotfollah Davoodi, Jamshid Yazdani Charati, Maryam Moazeni, Mahdi Abastabar, Iman Haghani, Roghayeh Mirzakhani, Sabah Mayahi, Weihua Pan
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خلاصه مقاله: Bacterial or virus co-infections with coronavirus disease 2019 (COVID-19) have been reported in many studies, however, the reported cases on COVID-19 associated mold infections among severely ill patients was also increased. In this present study we aimed the COVID-19 associated with pulmonary fusariosis (CAPfusariosis) among mechanically ventilated patients in intensive care units of Mazandaran province. Antifungal Susceptibility testing of the isolates was also done. In addition, we did also a literature review on previous published data on CAPfusariosis. During the study period, 302 COVID-19 patients were admitted to ICUs, among whom 105 were mechanically ventilated for ≥4 days. Probable CAPfusariosis was observed among 5.7% of patients (6/105). In patients with CAPfusariosis, Fusarium incarnatum (50%) was the most common followed by F. fujikuroi (16.6%), F. equiseti and F. solani (16.6%, each). Among 6 patients with Fusarium species growth, five patients had positive BAL GM index ≥1. F. equiseti showed the highest MICs against voriconazole (16 µg/ml), itraconazole, posaconazole, and isavuconazole (8 µg/ml each). F. solani had MIC 8 µg/ml against voriconazole. This report and existing published literature indicate COVID-19–associated pulmonary mold infection (CAPMI) is a neglected complication among mechanically ventilated COVID-19 patients admitted to ICUs, so that clinicians should keep alerting the possible occurrence of CAPfusariosis in critical COVID-19 patients
Keywords: Fusarium; COVID-19; Co-infection; SARS-CoV-2.
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