کاندیدیازیس دهانی و HIV کودکان در سراسر جهان، یک مطالعه مروری نظام مند و متاآنالیز

Zahra Rafat ©, Elahe Sasani, Mohammad Shenagari

کاندیدیازیس دهانی و HIV کودکان در سراسر جهان، یک مطالعه مروری نظام مند و متاآنالیز

کد: G-80419

نویسندگان: Zahra Rafat ©, Elahe Sasani, Mohammad Shenagari

زمان بندی: زمان بندی نشده!

برچسب: ویرایش شده

دانلود: دانلود پوستر

خلاصه مقاله: Oral candidiasis (OC) in HIV-infected pediatrics is a global issue of concern due to its association with dysphagia, malnutrition, and mortality. The present systematic review and meta-analysis is the first to determine the prevalence of OC in HIV-infected pediatrics across the world. We searched international (PubMed, Web of Science, Scopus, and Embase) databases for studies published between January 2000 to May 2020 reporting the epidemiologic features of OC in HIV-infected pediatrics. Inclusion and exclusion criteria were defined to select eligible studies. Data were extracted and presented according to PRISMA guidelines. The results of the meta-analysis were visualized as a forest plot. Heterogeneity was also analyzed using the I2, and τ2 statistics. The literature search revealed 1926 studies, of which 34 studies met the eligibility criteria, consisting of 4474 HIV-infected pediatrics from 12 different countries. The overall prevalence of OC among HIV-infected pediatrics was 23.9 % (95% CI 17.3–32.0 %) and Candida albicans was the most prevalent etiologic agent. Pseudomembranous candidiasis was the predominant clinical manifestation in HIV-infected pediatrics suffering from OC. The data from 11 articles demonstrated that antiviral therapy was significantly associated with a reduction in OC, while others show the opposite or did not mention any associations. A high level of I2 (I2 = 96%, P

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