بررسی قارچ شناسی و مولکولی پنومونی ناشی از پنوموسیستیس جیرووسی در مبتلایان به HIV و بیماران دچار ضعف ایمنی غیرمبتلا به HIV بستری در بخش های ریه ی بیمارستان های استان گیلان واقع در شمال ایران
نویسندگان: Zahra Rafat ©, Keyhan Ashrafi, Seyed Jamal Hashemi
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خلاصه مقاله: Background and Objectives: Pneumocystis jirovecii pneumonia (PJP) is a serious infection that usually affects those with
a weak immune system. Since the prevalence of this infection in Iran and in the world is not clearly defined, the present
study aimed to evaluate the incidence, clinical spectrum, and demographic characteristics of PJP among HIV and non-HIV
Materials and Methods: Bronchoalveolar Lavage (BAL) specimens were obtained from 3 groups of immunocompromised
patients, including acquired immunodeficiency syndrome (AIDS) patients, diabetic patients, and patients receiving immunosuppressive therapies. All were hospitalized in pulmonary units. The specimens were examined using microscopic methods
(Giemsa and calcofluor white staining) and the nested-PCR technique based on mtLSU-rRNA gene.
Results: A total of 120 BAL samples were collected. From 12.5% (5 from 40) of HIV-infected patients, 5% (2 from 40) of
patients receiving immunosuppressive therapies, and 2.5% (1 from 40) of diabetic patients Pneumocystis jiroveci was isolated. There was not any association between the prevalence of PJP and the patient's gender (p= 0.557) and age (p= 0.681).
Fever and dyspnea (n=7, 87.5%), nonproductive cough and abnormal auscultation sound (n=5, 62.5%), and also chills and
weight loss (n=2, 25%) were the documented clinical symptoms of PJP. Also, the results showed that none of the samples
had positive results for P. jiroveci with microscopic tests while using the nested-PCR method 8 samples had positive results.
Conclusion: Since PJP often causes symptoms that are similar to other illnesses, such as the flu or tuberculosis, clinical and
laboratory findings should be used simultaneously for making the final decision on drug administration.
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