Modeling uncertainty in risk assessment using control banding approach and Monte Carlo simulation for activities involved with nanomaterials
کد: G-12589
نویسندگان: Nafiseh Nasirzadeh ℗, Soqrat Omari Shekaftik ©, Farideh Golbabaei
زمان بندی: زمان بندی نشده!
برچسب: عوامل شیمیایی
دانلود: دانلود پوستر
خلاصه مقاله:
زمینه و هدف
Introduction and Objectives: Despite enormous benefits, nanotechnology poses emerging concerns for human health and the environment that has led to the development of risk assessment methods for activities involving these materials. So the aim of this study was to assess the occupational risk of activities involved with nanomaterials by two Control Banding-based (CB-based) methods and risk modeling by Monte Carlo simulation.
روش کار
Materials and Methods: In 2022, this cross-sectional study was managed in nano-medicine research laboratories of 3 medical universities in Tehran, Iran. These were among top-ranked universities in the field of medical nanotechnology which have approximately all infrastructures. Risk assessment was performed by two different methods; NanoTool and Guidance. We chose these two methods, because the NanoTool is the most popular and widely used CB-based method and Guidance is a simple method based on CB, which has minimal complexity compared to other methods. Data were analyzed using IBM SPSS 22.0 Software. Descriptive statistics was used to attain the objectives. In order to compare methods, risk levels of each method were converted into risk ratio (RR) and the consistency of two methods was examined by Cohen's Kappa. Also, Monte Carlo simulation was used to determine uncertainties and sensitivity results, using Crystal Ball tool.
یافتهها
Results: Most of the activities had risk level 2 (RL2) and category A (lowest risk level) based on NanoTool and Guidance methods, respectively. Only in one laboratory, risk level was 3 and category C (highest risk level) based on NanoTool and Guidance methods, respectively. Also, the highest severity of exposure to nanomaterials belonged to “preparation of suspension of metal nano-polymers”, and the highest probability of exposure was related to “manufacturing of carbon nanocomposites”. There was a significant relationship between the risk levels of two methods (P=0.003), and Cohen's Kappa showed a good consistency between two methods (K=0.61, p-value=0.01). Mont Carlo simulations showed that in NanoTool method risk was highly influenced by probability of exposure (50.9%). Dustiness (62.6%) and frequency of operations (17.4%) had high effect on probability of exposure. Also, in Guidance method, risk was highly influenced by exposure (51.3%).
نتیجهگیری
Conclusion: Since NanoTool method uses more diverse parameters for risk assessment, choosing control measures based on its results seems more reasonable. However, Guidance can be used as a method for initial assessments. Also, according to Mont Carlo results, it is recommended that control measures for nanomaterials-involved activities should be provided to reduce exposure.
کلمات کليدی
Risk assessment, Mont Carlo, Nanomaterial, Control Banding, NanoTool, Guidance,
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