RNA-based COVID-19 vaccines; Advantages and disadvantages

Fereshteh Ebrahimi ©

RNA-based COVID-19 vaccines; Advantages and disadvantages

کد: G-24357

نویسندگان: Fereshteh Ebrahimi ©

زمان بندی: زمان بندی نشده!

برچسب: ژنتیک پزشکی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus that is highly pathogenic and has caused the recent worldwide pandemic. Currently, considerable efforts have been put into developing effective and safe drugs and vaccines against SARS-CoV-2. Gene-based vaccines use genetic instructions, in the form of DNA or RNA, for a SARS-CoV- 2 protein that stimuli an immune response and have shown promising results encompassing both humoral and cell-mediated immune responses in previous studies, supporting their implementation for COVID-19 vaccine development. In this review article, we decided to survey the advantages and disadvantages of RNA-based COVID-19 vaccines.


This systematic review was conducted to outline comprehensive studies published in PubMed, Scopus, and Google scholar databases from 2020 to 2021 by using 4 keywords 22 articles were screened, and 9 were totally included.


The overwhelming advantages of mRNA vaccine over traditional vaccines include versatility and rapid development and its synthetic nature and sequence-independent manufacturing allow extremely fast and flexible vaccine design and production. Besides, the mRNA vaccine is more stable, easily translatable, rapidly producible, and usually economical. These vaccines possess much higher biosafety than DNA-based vaccines as the translation of the antigens takes place in the cytoplasm rather than the nucleus, thus much less possible for the mRNA to integrate into the genome. Low temperature and pH are vital to the preservation of DNA integrity in the long term. In contrast, RNA products are very sensitive to temperature and should always be kept at −70 °C during storage and distribution. The presence of ribonucleases can destroy the RNA vaccine product; therefore synthesis, purification, and storage of the product must be done in absence of enzymes to elongate its shelf-life.


Despite the many advantages over the small disadvantages of the RNA-based vaccine platform, this system can be more efficient than others in producing vaccines for various diseases, especially COVID-19.


RNA-based vaccines; COVID-19; Advantages; disadvantages

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