Association of asprosin concentration and atherogenic lipid profile in umbilical cord blood: a cross-sectional study

Zahra Mohammadi Abgarmi, Hafez Heydari ©, Seyyede Arasteh Aldaghi, Mohammad Miri , Zohreh Abdolvahabi

Association of asprosin concentration and atherogenic lipid profile in umbilical cord blood: a cross-sectional study

کد: G-67125

نویسندگان: Zahra Mohammadi Abgarmi, Hafez Heydari ©, Seyyede Arasteh Aldaghi, Mohammad Miri , Zohreh Abdolvahabi

زمان بندی: زمان بندی نشده!

برچسب: بیوشیمی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Elevated lipids in umbilical cord blood affect fetal programming, which can lead to a higher risk of developing cardiovascular disease in later life. However, the causes of changes in lipid profile of umbilical cord blood are not clear yet. this study aimed to determine the association of asprosin concentrationwith TAG, TC, HDL-C, LDL-C concentrations and TAG/HDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratio in umbilical cord blood.

Methods

This cross-sectional study was based on 150 mother-pair of birth cohort study in Sabzevar, Iran. Multiple linear regression was used to estimate the association of lipid concentration and lipid ratios with asprosin in cord blood samples controlled for the relevant covariates.

Results

In fully adjusted models, each 1 ng/ml increase in asprosin was associated with 0.19 (95% CI: 0.06, 0.31, P < 0.01), 0.19 (95% CI: 0.10, 0.29, P < 0.01), 0.17 (95% CI:0.09, 0.25, P < 0.01), 0.17 (95% CI: 0.09, 0.25, P < 0.01), 0.01 (95% CI: 0.00, 0.013, P < 0.01), 0.01 (95% CI: 0.01, 0.01, P < 0.01), 0.01 (95% CI: 0.01, 0.01, P < 0.01) and 0.01 (95% CI: 0.01, 0.01, P < 0.01) increase in TAG, TC, LDL-C, TAG/HDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratio respectively.

Conclusion

Overall, our findings support the link between cord asprosin concentration and development of atherogenic lipid profile in newborns. Further studies are needed to confirm the findings of this study in other populations.

Keywords

Asprosin; Lipid profile; Umbilical cord blood; Triglyceride; Cholesterol

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