Prevalence of Helicobacter Pylori antibodies titer with ELISA in blood and compared to stool antigen in Urmia, Iran, 2021
کد: G-87509
نویسندگان: Masoum Gholami, Mohammad Yousefzadeh ©
زمان بندی: زمان بندی نشده!
برچسب: باکتری شناسی پزشکی
دانلود: دانلود پوستر
خلاصه مقاله:
Background and Aim
Helicobacter pylori (H. pylori) is one of the most common human infections in the world. In developing countries, most children (80%) are infected by the age of 10, while in advanced countries, the prevalence of H. pylori and gastritis increases with age. This study aimed to evaluate the antibody titer of IgG and IgM anti-Helicobacter pylori using the ELISA method and to investigate its relationship with stool antigen.
Methods
This study was conducted in 2020 on 100 patients. After blood sampling and serum isolation, IgG and IgM antibody titers were measured by the ELISA method. On the other hand, stool antigens were also tested using the Helicobacter pylori Rapid Kit.
Results
showed that 51% of IgG positive and 54% of H.pylori Ag stool positive were studied. Other results showed that 33% of patients were both IgG positive and H.pylori Ag stool positive. No association was found between H. pylori Ag stool and IgG with IgM.which means that the IgM antibody was negative in all patients. That is, H.pylori Ag stool is the best and most accurate method for Helicobacter pylori screening.
Conclusion
Simple methods based on the search for antibodies and antigens with high sensitivity and specificity are available. The advantage of ELISA in addition to its high sensitivity and specificity also determines the antibody class. IgG has a higher diagnostic value and prognosis and represents a chronic stage of the disease. IgM is not very useful in the diagnosis of Helicobacter pylori and can be said to be an insensitive indicator of acute infection. On the other hand, for detection of Helicobacter pylori antigen in stool rapids can also be very useful due to its high accuracy and low test time.
Keywords
Helicobacter Pylori; antibodies titer; ELISA; stool
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