Descurainia Sophia attenuates Gentamicin-induced renal insufficiency by reducing inflammation, and apoptosis in Rats
کد: G-28345
نویسندگان: Hassan Askari, Sara Shojaei-Zarghani ©, Reza Barati-Boldaji
زمان بندی: زمان بندی نشده!
برچسب: سم شناسی
دانلود: دانلود پوستر
خلاصه مقاله:
Background and Aim
Recent studies have tried to suggest an efficient agent to prevent gentamicin (Gm) induced renal failure. In this study, we evaluated the potential renoprotective effects of Descurainia sophia against Gm-induced nephrotoxicity in rats.
Methods
Forty rats were categorized in five groups (n = 8 per group). Control group was treated with normal saline. In four experimental groups, the rats were initially treated with normal saline (A), 800 (B), 1600 (C) and 2400 (D) mg/kg Descurainia sophia respectively for four weeks. Then, the animals of experimental groups were administered with Gm (80 mg/Kg) for 7 consecutive days.
Results
Serum BUN level signifcantly increased in group 1. However, pretreatment with either 800, 1600 or 2400 mg/ kg of Descurainia sophia dose-ependently prevented elevation of BUN following Gm treatment in Wistar rats with the most efficient dose that was 2400 mg/Kg. The rats in group 1 also had signifcantly increased serum creatinine level while those received various doses of Descurainia sophia showed signifcantly lower creatinine level with the lowest level observed in 2400 mg/kg group The rats received normal saline showing signifcant increase in urinary Na+ concentration and fractional excretion of sodium (FeNa+). On the other hand, pretreatment with either 800, 1600 or 2400 mg/Kg of Descurainia sophia signifcantly decreased urine Na+ concentration and FeNa+ at all the studied doses. Serum BUN, creatinine, cholesterol, and triglycerides level, as well as urinary excretion of Na+ significantly increased in group A. Furthermore, Gm induced inflammatory cells infiltration, apoptosis, and renal cells injuries in rats were pretreated with normal saline. However, in the animals pretreated with Descurainia sophia extract there were significant and dose-dependent reductions in blood and urine markers, apoptosis rate, and inflammatory cells infiltration in renal tissues.
Conclusion
Overall, Descurainia sophia showed significant renoprotective effects against Gm-induced AKI by alleviating biochemical and histological markers of renal toxicity.
Keywords
Gentamicin; Nephrotoxicity; Inflammation; Apoptosis
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