Investigation of antibacterial effect of Ferula macrocolea extract and quantity determination of inhibitory effect on 4 standard strains of gram-positive and gram-negative bacteria.
نویسندگان: Atefeh Akbari ©
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Background and Aim
Today Antibiotic resistance is one of the global concerns in medicine. due to the increasing emergence of antibiotic-resistant bacteria and the problems with their treatment, the use of alternative methods to increase effectiveness and reduce drug resistance is important. In traditional medicine, the use of ferula plants due to it is various active chemical compounds with antibacterial, antioxidant, and cytotoxic activity, has attracted the attention of researchers, Because many studies have been performed on other species of Ferula. the aim of this study was to investigate the antimicrobial effect of Ferula macrocolea extract on 4 standard strains of gram positive and gram-negative bacteria.
the study was performed on 4 standard bacterial strains of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Bacillus subtilis. First, Ferula essential oil was extracted. Microbial suspension with specific and standard concentrations was prepared in Müller-Hinton Broth medium. antimicrobial properties of the essential oil on the desired bacteria were performed using two methods of disk diffusion and micro broth dilution according to the CLSI standards.
The results of this study showed that Ferula extract has a different antimicrobial effect on all strains. The highest and lowest antimicrobial and inhibitory effects of this extract were reported on Bacillus subtilis and Staphylococcus epidermidis, respectively.
In our study, ferula extract had different inhibitory and lethal effects on all standard gram-positive and gram-negative strains in this experiment. it was shown that a very small concentration of extract would be effective in inhibiting and killing the Bacillus subtilis strain, while the Staphylococcus aureus strain would be inhibited in higher concentrations of this extract.
Ferula macrocolea; antibiotic resistance; antibacterial effect; gram-positive; gram-negative bacteria
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