Similarities between COVID-19 infection and rheumatoid arthritis; finding a roadmap to treat the disease

Mohammadjavad amini noghondar, Hossein Javid ©

Similarities between COVID-19 infection and rheumatoid arthritis; finding a roadmap to treat the disease

کد: G-34095

نویسندگان: Mohammadjavad amini noghondar, Hossein Javid ©

زمان بندی: زمان بندی نشده!

برچسب: بیوشیمی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

The role of inflammatory responses in the progression of COVID-19 disease has evolved a hypothesis that perhaps the SARS-CoV-2 virus might exploit the immune system to induce its pathogenesis. Analyzing the profile of secreted cytokines in COVID-19 patients also revealed a similarity between the immune response of the SARS-CoV-2 virus and arthritis rheumatoid. Moreover, the observation of musculoskeletal symptoms in the majority of COVID-19 patients also shed more light on the possible resemblance between the pathogenesis of these diseases. These findings are promising, as it is possible that some of the anti-arthritis treatments could also be used for the management of COVID-19 disease. Although vaccines are the only weapon against the SARS-CoV-2 virus, the emergence of the new variants of the virus necessitates the identification of several therapeutic strategies to prevent the spread of the virus. Among the drugs used in the treatment of arthritis rheumatoid, chloroquine/hydroxychloroquine seems to be a promising option for the treatment of COVID-19 disease.

Methods

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Results

This agent also showed efficacy against other SARS coronaviruses. Through increasing the endosomal PH and suppression of toll-like receptors (TLRs), chloroquine not only might prevent the fusion of the virus into the target cells but also block the immune responses. The results of the clinical investigations also showed that the administration of chloroquine to COVID-19 patients prevents the exacerbation of pneumonia and reduces the duration of the disease. In addition to chloroquine, IL-1 and IL-6 inhibitors, TNF inhibitors, and Janus kinase (JAK) inhibitors also seem to be effective in controlling COVID-19 disease.

Conclusion

It is believed that JAK inhibitors could prevent receptor-mediated endocytosis of the virus and thereby prevent the involvement of the lungs. Taken together, although there are still mysteries about the SARS-CoV-2 virus, finding similarities between this viral infection and other diseases could help find a roadmap for its management.

Keywords

SARS-CoV-2 virus; Inflammatory responses; Chloroquine; JAK inhibitors; Treatment.

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