Assessment of circulating Vitamin D in adult burned persons according to total body surface areas (TBSAs) burned
نویسندگان: Majid Khoshmirsafa ©, Sepideh Moradkhani, Kobra Entezami, Seyed Mohammad Masoodian, Abolfazl Omidifar, Mahnaz Bahramian, Masoumeh Najafi
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Background and Aim
Regards to few researches, Vitamin D has a significant role in the immune system. This study aimed to evaluate serum concentration of Vitamin D, Calcium, Magnesium, and Phosphorous in adult burned persons according to the different total body surface areas (TBSAs) of burns in the 1st, 3rd, and 7th days.
In this study, 30 individuals as healthy controls (HC) group and 50 individuals with various degrees of burn injuries were participated. With reference to the burn of TBSAs %, the burned persons were categorized into three groups: G1 (N equal 25): 20%-50%TBSAs burned (mean ± SD age: 39.5±14.1); G2 (N equal 10): 50%70% TBSAs burned (mean ± SD age: 32.4±9.4), and G3 (N equal 15): more than 70%TBSAs burned (mean ± SD age: 32.3±15.5).
The mean ± SD of age in burned persons and HC group were 35.9±14.3 and 40.8±10.9, respectively. In general, burned persons compared with HC group indicated no significant differences for serum total Calcium, Magnesium, and Phosphorous. A significant decrease of Vitamin D serum levels was seen in the burned persons in comparison to HC group (p less than 0.001). However, there was no significant discrepancy during 1st, 3rd and 7th days of total burned persons. In addition, Vitamin D serum levels in three groups of TBSA burned in 1st, 3rd, and 7th days were evaluated. There was a significant decrease in Vitamin D serum concentrations among three TBSAs burned groups (G3 burned in the 3rd and 7th days) (p less than 0.05).
Vitamin D is usually found to be rare in burned persons especially in adult with severe burning. So, an important role of Vitamin D as an immunomodulator in the immune system might be useful in patients with very low levels of serum Vitamin D. More studies are required to prove definite guidelines respecting the supplementation of nutrients in burned persons.
Adult;Burn;Serum Vitamin D; TBSAs
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