Superinfections caused by Acinetobacter baumannii and Pseudomonas aeruginosa among hospitalized COVID-19 patients admitted to ICU

Mohammad Abavisani, Kiarash Ghazvini ©, Hanieh Sadat Riahi

Superinfections caused by Acinetobacter baumannii and Pseudomonas aeruginosa among hospitalized COVID-19 patients admitted to ICU

کد: G-45390

نویسندگان: Mohammad Abavisani, Kiarash Ghazvini ©, Hanieh Sadat Riahi

زمان بندی: زمان بندی نشده!

برچسب: میکروب شناسی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Hospitalization due to the invasive manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to the emergence of superinfections. We aimed to describe the prevalence of hospital-acquired Acinetobacter baumannii and Pseudomonas aeruginosa and their pattern of antibiotic resistance among the COVID-19 inpatients admitted to ICU during the summer of 2021 in Ghaem hospital, Mashhad, Iran.

Methods

This retrospective cohort study was performed in all inpatients who had positive SARS-CoV-2 reverse transcription PCR (RT-PCR) in nasal or respiratory tract samples during July, August, and September 2021. Therefore, data of eligible inpatients were investigated by the virtue of electronic health records. The reported bacteria which were diagnosed ≥48 hours after admission were included in our study. The obtained outcomes were analyzed by SPSS software version 22.

Results

Eight hundred and ninety-four Hospitalized patients were qualified for our study of which 45 (5.03%) Acinetobacter baumannii and 24 (2.68%) Pseudomonas aeruginosa were isolated as superinfection. The mean (SD) time from admission to diagnosis of superinfection was 12 (16.2) days. The most common sources of collected bacteria were respiratory samples (22 (48.8%) Acinetobacter baumannii and 14 (58.3%) Pseudomonas aeruginosa) and blood culture (17 (37.7%) Acinetobacter baumannii and 8 (33.3%) Pseudomonas aeruginosa). Imipenem (21, 87.5%), meropenem (15, 62.5%) and amikacin (12, 50%) were the antibiotics displaying the highest resistance frequency for Pseudomonas aeruginosa. besides, all isolates of Acinetobacter baumannii were resistant against imipenem, meropenem and piperacillin-tazobactam. Doxycycline (26, 57.7%) and piperacillin-tazobactam (12, 50%) showed the lowest frequency of resistance among Acinetobacter baumannii and Pseudomonas aeruginosa, respectively. Crude mortality rate in Acinetobacter baumannii and Pseudomonas aeruginosa superinfected patients concluded as 13 (28.8%) and 6 (25%), respectively.

Conclusion

Our findings emphasized the prevalence of two important hospital-acquired superinfections. Promoting appropriate antibiotic usage as a consequence of antimicrobial stewardship strategies has a critical role in reviving inpatients.

Keywords

COVID-19; Superinfection; Acinetobacter baumannii; Pseudomonas aeruginosa

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