Frequency and Antimicrobial Resistance Patterns of Urinary Tract Bacteria Isolated in a Zanjan Educational Hospital in 2016-2018
نویسندگان: Erfan Fakheri, Niloufar Kazemi, Narges Moradi, Bahman Mirzaei ©
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Background and Aim
Bacteria play a major role in UTIs; therefore, it is necessary to be aware of their regional prevalence and the causative pathogens for better prognosis, rapid treatment and elimination of the infectious agents in clinical settings. This study aims to evaluate the prevalence of bacterial isolates involved in UTI samples and their antibiotics resistance pattern in two educational hospitals in North West of Iran.
A cross-sectional study was designed to analyze 4214 urine samples were collected from hospitalized patients in Valie-Asr hospital in Zanjan, Iran. Samples were cultured in two media including MacConkey agar and blood agar. The standard media such as oxidase and coagulase were prepared for all of the culture isolates. Considering the results and the Bergeys̓ microbiology book guidelines, bacterial strain was identified. Afterwards, disk diffusion method was utilized for positive cultures. Finally, data were entered to SPSS 26.
The study population consisted of a total number of 3582 patients with positive urine cultures, including 56% females and 44% males. E. coli and Staphylococcus epidermidis were the most frequently isolated gram negative and gram-positive bacteria in the urine samples with isolation rates of 53.43% and 15.99%, respectively. In gram negative bacteria, nitrofurantoin and vancomycin represented the smallest resistance rates at 25.27% and 26.74%. Piperacillin showed the least efficacy with a resistance rate of 76.04%. In gram positive bacteria, vancomycin and gentamicin showed more promise with respective resistance rates of 19.34% and 27.34%. The highest resistance was associated with ampicillin (68.61%).
Gram-negative bacteria were significantly more prevalent than gram positive-bacteria in this study and E. coli was the pathogen behind more than half of the infections. while Vancomycin had the lowest resistance rate for both gram-positive and gram-negative bacteria, it is considered as a last-resort antibiotic, therefore alternatives have priority for treatment procedure.
Nosocomial infections (NIs); urinary tract infections (UTIs); antibiotics resistance pattern
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