Evaluation of antibacterial and anti-biofilm activity of thyme essential oil on some bacterial pathogens from cystic fibrosis patients

Zeinab Jafari ©, Ahya Abdi Ali, Ameneh Elikaei

Evaluation of antibacterial and anti-biofilm activity of thyme essential oil on some bacterial pathogens from cystic fibrosis patients

کد: G-35106

نویسندگان: Zeinab Jafari ©, Ahya Abdi Ali, Ameneh Elikaei

زمان بندی: زمان بندی نشده!

برچسب: میکروب شناسی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Cystic fibrosis (CF) is an autosomal recessive disease characterized by respiratory, gastrointestinal, and reproductive systems problems. Patients with CF often suffer from chronic pulmonary infections due to the Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae and some other pathogens. These bacteria produce biofilms that make them more resistant to conventional antibiotics, in addition to their innate antibiotic resistance. Consequently, to improve global health, it is vital to identify innovative antibacterial medicines to combat multidrug-resistant strains. Essential oil of some medicinal plants including thyme exhibits broad-spectrum antimicrobial activity. In this study, we studied the antibacterial and antibiofilm activity of thyme essential oil on common bacterial pathogens from CF patients' lung infections.

Methods

Minimum inhibitory concentration (MIC) and Minimum biofilm inhibitory concentrations (MBICs) of thyme essential oil were determined against 30 isolates from three different genera including P. aeruginosa, S. aureus and K. pneumoniae using microdilution method as described by Clinical and Laboratory Standards Institute (CLSI). TTC indicator was used for determining of MBIC test.

Results

S. aureus was shown to be the most sensitive strain, whereas P. aeruginosa was found to be the most resistant. Compared to the other two bacteria, K. pneumoniae showed intermediate resistance. K. pneumoniae, P. aeruginosa, and S. aureus had MIC values of (52.88

Conclusion

Thyme essential oil has a powerful effect on planktonic cells and bacterial biofilm, and it could be utilized as an alternative to antibiotics in the treatment of CF patients' lung infections. Thymol and carvacrol, two key components of thyme, are significant in the antibacterial properties of the medicinal plant.

Keywords

Biofilm; Cystic fibrosis; MIC; MBIC; Thyme

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