Magnesium supplementation may not be protective against carboplatin induced nephrotoxicity but may be beneficial for children suffering malignancies: A Randomized Clinical Trial
نویسندگان: Melika Gharibi , Marzie Alizadeh Hadadhania , Abdorrahim Absalan , Aygin Eghbali , Roghayeh Rahimi Afzal , Ali Ghasemi, Aziz Eghbali , Kazem Ghaffari ©
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Background and Aim
Magnesium oxide is proposed to be effective in prevention of nephrotoxic impact of carboplatin therapy. The aim was to
evaluate the magnesium oxide supplementation effect on serum creatinine, blood urea nitrogen (BUN) and glomerular
filtration rate (GFR) in cancerous children
18 children were treated with 250 mg/day magnesium oxide and other 18 children with placebo for 14 days before onset of carboplatin chemotherapy based on the routine protocols in oncology. Serum creatinine (Cr), BUN and GFR were measured and
compared before, on day 3 and 7 of magnesium carboplatin therapy
There were 7 (38.89%) and 12 (66.67%) male patients in treatment and control groups, respectively. Serum Cr and BUN were increased significantly 3 and 7 days after intervention in both groups. There was an insignificant difference for serum Cr and BUN between treatment and control groups before intervention, 3 days or 7 days after carboplatin administration onset (p> 0.05). The GFR was reduced significantly from 101.38±14.67 to 90.11±10.52 mL/min/1.73m² in treatment and from 97.5±9.71 to
92.33±10.61 mL/min/1.73m² in control group. After 7 days the GFR was reduced to 84.11±12.47 mL/min/1.73m² in treatment
and 85.38±10.66 mL/min/1.73m² in control group (p= 0.371).
Current study shows that magnesium supplementation did not prevent carboplatin-induced nephrotoxicity in cancerous
children. Anyway, we propose magnesium oxide supplementation for such patients considering this fact that magnesium in an
essential element for cell and tissue growth, maintenance and metabolism.
carboplatin; magnesium; nephrotoxicity; pediatrics
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