Molecular Characterization of Fungal Colonization on the Provox™ Tracheoesophageal Voice Prosthesis in Post Laryngectomy Patients

Hasti Kamali Sarvestani ©, Roshanak Daie Ghazvini, Mohsen Gerami Shoar, Shima Aboutalebian, Saham Ansari, Zahra Rafat, Muhammad Ibrahim Getso

Molecular Characterization of Fungal Colonization on the Provox™ Tracheoesophageal Voice Prosthesis in Post Laryngectomy Patients

کد: G-08953

نویسندگان: Hasti Kamali Sarvestani ©, Roshanak Daie Ghazvini, Mohsen Gerami Shoar, Shima Aboutalebian, Saham Ansari, Zahra Rafat, Muhammad Ibrahim Getso

زمان بندی: زمان بندی نشده!

برچسب: قارچ شناسی پزشکی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Successful voice rehabilitation is critical for the patients' voice communication after surgery. Tracheoesophageal voice prostheses (TVPs) have been the gold standard in rehabilitation, after laryngectomy, producing faster and premier voicing towards esophageal speech. Fungal colonization shortens the device’s lifetime and leads to prosthesis dysfunction, leakage, and subsequent respiratory infection unless replaced with a new one immediately. Therefore, in the current study, we aimed to investigate the fungal colonization patterns and to propose prophylactic measures that shall increase the longevity of voice prostheses to decrease patients’ discomfort and health cost.

Methods

Failed TVPs were removed - due to leakage and/or aspiration - from 66 laryngectomized patients and examined. Fungal colonization patterns were assessed using DNA sequencing techniques. Furthermore, the susceptibility to fluconazole, amphotericin B, nystatin, and white vinegar was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines.

Results

Resident fungal species from the upper airways colonized all the 66 TVPs (100%). Diabetes (31%) and smoking (98%) were the predominant underlying disease and predisposing factors, respectively. Among the 79 fungal agents isolated from the 66 TVPs, Candida glabrata (n=25, 31.7%) was the most common. A significant reduction in minimum inhibitory concentration (MIC) values was observed for white vinegar when used alone.

Conclusion

Conclusion: Our study revealed that white vinegar at a very low concentration could decrease the amount of fungal colonization on TVPs without any adverse effects; its wide accessibility and affordability ensure a decrease in the overall health cost.

Keywords

Voice prostheses; fungal colonization; antifungal susceptibility test; white vinegar; minimum inhibitory concentration; total laryngectomy

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