A clinical association between Toll-Like Receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients; a case control study

Mohammad Ali Moradkhani, Mahmoud Mahami-Oskouei , Ehsan Ahmadpour, Mahsa Lotfinezhad, Jafar Noori , Zahra Alizadeh, Adel Spotin ©

A clinical association between Toll-Like Receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients; a case control study

کد: G-46503

نویسندگان: Mohammad Ali Moradkhani, Mahmoud Mahami-Oskouei , Ehsan Ahmadpour, Mahsa Lotfinezhad, Jafar Noori , Zahra Alizadeh, Adel Spotin ©

زمان بندی: زمان بندی نشده!

برچسب: انگل شناسی پزشکی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

The recurrence of hydatid cysts in cystectomy patients has dramatically remained a serious concern within the surgical community. Predisposing factors for recurrence of hydatid cysts remained to be identified. Toll-like receptor (TLR) plays a pivotal role in bridging between acquired and innate immunity in cystic echinococcosis (CE) infection.

Methods

117 CE patients including 66 acute hydatidosis (AH; primary infection) and 51 recurrent hydatidosis (RH; chronic infection), and 117 ethnically matched healthy control (HC) were investigated from endemic regions of Iran in the period of 2015 to 2018. CE patients were definitely confirmed using histopathological and immunological assays. Genotyping of TLR2 Arg753Gln was carried out by restriction fragment length polymorphism and sequencing.

Results

The homozygous mutant-type TLR2 Gln/Gln (A/A) was represented to be associated with the occurrence of RH (P=0.04) and conferred a 9 fold risk for susceptibility, while the heterozygous mutant-type TLR2 Arg/Gln (G/A) indicated a tendency to be associated with the occurrence of RH (P=0.07). There was no discrepancy in the frequency of TLR2 Arg753Gln haplotypes between AH patients and HC individuals (P=0.09). The mutant allele A was observed to be a risk factor for susceptibility to RH patients.

Conclusion

Our results point to a clinical association between TLR2 Arg753Gln haplotypes with RH.

Keywords

Recurrence cystic echinococcosis; Toll-like receptor 2; Genetic polymorphism; Unsuccessful postoperative

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