Potential Use of umbilical cord mesenchymal stem cells for the improving of COVID-19 Patients
نویسندگان: Mohammad Khani-Eshratabadi, Jamal Motallebzadeh khanmiri, Amirreza Nasirzadeh, Mahdie Nematzade, Amir Talebpour, Seyed Hadi Mousavi ©
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Background and Aim
The SARS-CoV-2 virus is a member of the coronavirus family that caused the COVID-19 respiratory disease epidemic in China before the global pandemic of the disease in late 2019. The virus's genome is of 79% similarity to that of the SARS-CoV virus, using the ACE2 receptor to enter its target cells. The most common symptoms of this disease include fever, cough, pulmonary involvement, and sometimes gastrointestinal symptoms.The aim of this review study, use therapeutic potential of umbilical cord mesenchymal stem cells in COVID-19.
Our study was based on PUBMED and GOOGLE SCHOLAR databases from December 2019 to 2021 by related key words such as: "COVID-19'', "SARS-CoV-2", mesenchymal stem cells", "umbilical cord" nd "Immunomodulatory effects". Also was searched with the key words: "mesenchymal stem cells" and "umbilical cord" without time limit.
A decline in both the number and function of lymphocytes and a severe increase in leukocyte inflammatory activity are among the most obvious immunological complications of this disease. If the immune system response to the virus is inadequate, the disease can become acute. Immune cells activity leads to a sharp increase in the number of blood cytokines, causing "cytokine storm," which in turn can cause systematic damages to the heart, lungs, and kidneys, and ultimately may lead to death. Mesenchymal stem cell therapy offers a promising approach to reducing the destructive impacts of infection in COVID-19 patients. Mesenchymal stem cells can secrete immune-modulating factors that suppress cytokine storms.
Furthermore, the role of mesenchymal stem cells in preventing cell death and inhibiting tissue fibrosis has been well demonstrated. This review shows available clinical trials that have tapped into the therapeutic potential of the umbilical cord mesenchymal stem cells in COVID-19 patients.
mbilical cord; Mesenchymal stem cell; COVID-19; SARS-CoV-2; Immunomodulatory effects; Clinical trials
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