Sex differences in the renal vascular functions of Mas receptors in two-kidney-one-clip hypertension
نویسندگان: Zahra Pezeshki ©, Mehdi Nematbakhsh
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فیزیولوژی و فارماکولوژی
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Background and Aim
Hypertension is a complex condition which induces abnormalities such as renal dysfunction. The prevalence and severity of hypertension is gender dependent with more symptoms in males than in females. Also the activity of renal renin angiotensin systems (RAS), are gender related. In this study we investigated sex differences in renal vascular responses to angiotensin II (Ang II) administration without Ang II type 1 and Mas receptors antagonists in the 2K1C rat model of renovascular hypertension.
Male and female 2K1C rats were divided into 4 experimental groups (2 of each sex) treated with losartan or A779+losartan. Responses of mean arterial pressure (MAP), renal blood flow (RBF), renal vascular resistance (RVR) to Ang II were determined.
No gender differences were observed when the AT1R was blocked. While The RBF response to Ang II in A779+Losartan groups was gender related. With the stronger RBF response to Ang II in A779+Losartan 2K1C female treated groups.
The stronger RBF response to Ang II in A779+Losartan 2K1C female treated groups related to greater distribution and function of ACE2/Ang 1-7/MasR arm of the RAS in female 2K1C rats. Therefore, rather than blocking the ACE/AngII/AT1R axis , activating the ACE2/Ang 1-7/MasR axis of the RAS may be more effective in improving the renal and systemic side effects of Ang II dependent hypertension in the female but not in male.
Renal blood flow; angiotensin II; renovascular hypertension;gender
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