Correlation between Insulin Resistance and Polycystic Ovary Syndrome

Mehrdad Ostadpoor ©, Majid Gholami - Ahangaran, Seyyed Hossein Heidari

Correlation between Insulin Resistance and Polycystic Ovary Syndrome

کد: G-79452

نویسندگان: Mehrdad Ostadpoor ©, Majid Gholami - Ahangaran, Seyyed Hossein Heidari

زمان بندی: زمان بندی نشده!

برچسب: بیوشیمی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Polycystic Ovary Syndrome (PCOS) is a heterogeneous disorder presenting with several complaints including ovarian dysfunction, hyperandrogenism, menstrual irregularity, insulin resistance (IR), metabolic disorder and obesity. This syndrome is associated with features of the metabolic syndrome including type 2 diabetes (T2D), hypertension, and dyslipidemia. Insulin resistance is associated with consequent hyperinsulinemia, which activates excessive ovarian androgen production, leading to polycystic ovary syndrome development.

Methods

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Results

Articles show between 44% and 70% of women with polycystic ovary syndrome are insulin-resistant. Recent studies suggest that hyperinsulinemia, due to increased B-cell secretory capacity, is a prominent feature in polycystic ovary syndrome subjects independent from body weight, which drives levels of androgen excess in polycystic ovary syndrome. Clinical trials had also verified abnormal glucose tolerance leads to type 2 diabetes in polycystic ovary syndrome women. Articles demonstrated many women with polycystic ovary syndrome have insulin resistance beyond that predicted by their body mass index, with 50–70% of these women demonstrating insulin resistance by various measures. Other articles show insulin resistance and hyperinsulinemia play a role in the reproductive, and endocrine features of polycystic ovary syndrome by contributing to hyperandrogenism and disruption of gonadotropin secretion.

Conclusion

Insulin resistance is part of the pathogenesis of polycystic ovary syndrome and is associated with increased risk of type 2 diabetes in polycystic ovary syndrome also the individual family histories of type 2 diabetes and obesity will increase the prevalence of both diseases in women with polycystic ovary syndrome.

Keywords

Polycystic Ovary Syndrome; Insulin Resistance; Type 2 Diabetes

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