Survey of Inflammatory Parameters Extracted from Complete Blood Count in Cystic Fibrosis Patients
نویسندگان: Manouchehr Ahmadi Hedayati ©, Hero Yazdanpanah, Karo Servatyari
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Background and Aim
Cystic fibrosis (CF) known as an autosomal recessive genetic deficiency in childhood is a systemic disease following complicated chronic lung infections. This study aimed to investigate the inflammatory parameters extracted from Complete Blood Count (CBC) test in CF patients hospitalized from 2010 to 2020 in a teaching hospital, Sanandaj, Kurdistan, Iran.
A cross-sectional study was planed based on patient,s documents in Sanandaj,s hospitals from 2010 to 2020 . 57 patients suspected of CF with a positive family history or symptoms of growth retardation, chronic cough, fatty stools, and meconium ileus were examined. 19 and 38 patients were with and without CF, respectively. The extracted CBC test parameters, including the NLR (Neutrophil-to-lymphocyte ratio), PLR (Platelets-to-lymphocyte ratio), and RPR parameters (RDW-to- platelets ratio), were measured and compared in tow groups using an independent T-test or its corresponding nonparametric test, Mann-Whitney U test.
The mean and standard deviation (SD) age of patients with and without CF were 9.8 ±11.1 and 11.31±9.46, respectively. 14 (73.7%) of 19 CF patients were male. The mean of NLR (2.2±1.4) and PLR (11.2±4.93) in patients with CF was significantly higher than patients without CF. However, there was no significant difference between RPR in patients with and without CF (P=0.2). The odds ratio and its corresponding 95% confidence interval (CI) of the NLR and PLR indexes were 1.99 (1.12 - 3.54) and 1.22 (1.04 - 1.42), respectively. The RDW and WBC parameters were also statistically significant differences between the two groups.
The NLR and PLR parameters can be useful as a predictor for cystic fibrosis and patients' clinical course with the disease.
Cystic fibrosis, Neutrophil-to-Lymphocyte Ratio; Platelets-to-Lymphocyte Ratio; RDW-to- Platelets Ratio; Inflammatory Biomarkers; Inflammatory Activity
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