Survey of Inflammatory Parameters Extracted from Complete Blood Count in Cystic Fibrosis Patients

Manouchehr Ahmadi Hedayati ©, Hero Yazdanpanah, Karo Servatyari

Survey of Inflammatory Parameters Extracted from Complete Blood Count in Cystic Fibrosis Patients

کد: G-06493

نویسندگان: Manouchehr Ahmadi Hedayati ©, Hero Yazdanpanah, Karo Servatyari

زمان بندی: زمان بندی نشده!

برچسب: ایمنی شناسی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Cystic fibrosis (CF) known as an autosomal recessive genetic deficiency in childhood is a systemic disease following complicated chronic lung infections. This study aimed to investigate the inflammatory parameters extracted from Complete Blood Count (CBC) test in CF patients hospitalized from 2010 to 2020 in a teaching hospital, Sanandaj, Kurdistan, Iran.

Methods

A cross-sectional study was planed based on patient,s documents in Sanandaj,s hospitals from 2010 to 2020 . 57 patients suspected of CF with a positive family history or symptoms of growth retardation, chronic cough, fatty stools, and meconium ileus were examined. 19 and 38 patients were with and without CF, respectively. The extracted CBC test parameters, including the NLR (Neutrophil-to-lymphocyte ratio), PLR (Platelets-to-lymphocyte ratio), and RPR parameters (RDW-to- platelets ratio), were measured and compared in tow groups using an independent T-test or its corresponding nonparametric test, Mann-Whitney U test.

Results

The mean and standard deviation (SD) age of patients with and without CF were 9.8 ±11.1 and 11.31±9.46, respectively. 14 (73.7%) of 19 CF patients were male. The mean of NLR (2.2±1.4) and PLR (11.2±4.93) in patients with CF was significantly higher than patients without CF. However, there was no significant difference between RPR in patients with and without CF (P=0.2). The odds ratio and its corresponding 95% confidence interval (CI) of the NLR and PLR indexes were 1.99 (1.12 - 3.54) and 1.22 (1.04 - 1.42), respectively. The RDW and WBC parameters were also statistically significant differences between the two groups.

Conclusion

The NLR and PLR parameters can be useful as a predictor for cystic fibrosis and patients' clinical course with the disease.

Keywords

Cystic fibrosis, Neutrophil-to-Lymphocyte Ratio; Platelets-to-Lymphocyte Ratio; RDW-to- Platelets Ratio; Inflammatory Biomarkers; Inflammatory Activity

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