The Role of Thrombophilia Factors & Cytogenetic Analysis in Recurrent Pregnancy Loss (RPL) in Northeastern Iran
نویسندگان: Mohammad Reza Javan ©, Bahareh Moghimian-Boroujeni, Hossein Ayatollahi
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Background and Aim
Recurrent pregnancy loss (RPL) is the occurrence of three or more miscarriages before the 20th week of pregnancy. Thrombophilia factors are one of the main causes of RPL.
This retrospectively study was performed on women with more than two miscarriages. 620 patients’ documents with pregnancy loss were investigated. Based on number of pregnancy loss, the women between 22-37 ages divided to a pregnancy loss (PL) with less than three miscarriages (212) and RPL (180) group and 228 cases role out due to lack of information. In addition, we investigate 150 normal pregnant woman without any illness. Cytogenetics analysis like chromosomal culture and thrombophilia panel (MTHFR 677 C⁄T/ FV Leiden G1691A/Prothrombin G20210A (FII), ACE I/D, PAI1) were performed for all patients.
In the analysis between PL and RPL groups, none of the studied polymorphisms (MTHFR 677 C⁄T /Factor V Leiden /Prothrombin G20210A/ ACE I/D/ PAI-1) showed a significant relationship (P-value ˃ 0.05). Cytogenetic analysis showed 2 numerical and 9 structural abnormalities among both groups. Statistical analysis indicated significant association between number of abortion and age (P value= 0.005, r =0.139). We even realized that there was significant relationship between polymorphism number and recurrent number of abortion (P value= 0.018, r = 0.6).
We showed that polymorphisms analysis for thrombophilia factors is more precious test than cytogenetics analysis for RPL detection due to frequency in pregnant woman. We even indicated that no association was found between thrombophilia polymorphisms in PL and RPL groups. This means that screening for Factor V Leiden, prothrombin G20210A, MTHFR C677T, ACE I/D and PAI-1 and cytogenetic analysis in patients with a history of RPL is not recommended.
Pregnancy loss; Thrombophilia factors; Cytogenetic; Recurrent Pregnancy Loss
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