Effects of silver nanoparticles via ginger rhizome extract on Leishmania infantum: An in-vitro study
نویسندگان: Amir KarimiPourSaryazdi ©, Fatemeh Ghaffarifar, Abdolhossein Dalimi, Roya Omidi , Zeinab Moghadamizad
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انگل شناسی پزشکی
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Background and Aim
Leishmaniasis is a parasitic infection that is more common in the tropical and subtropical regions. According to the World Health Organization report, leishmaniasis is considered as a major global health issue in more continents. The current study was aimed to evaluate the effect of silver nanoparticles via Ginger rhizome extract on Leishmania infantum in-vitro.
Different concentrations of silver nanoparticles via Ginger rhizome extract promastigotes were investigated. We used promastigote assay and MTT methods to evaluate the toxicity and lethal effects of nanoparticles on L. infantum promastigotes. Also, lethal effects of nanoparticles were tested for macrophage cell with MTT assay.
At high concentrations, nanoparticles had a more lethal effect on parasites. According to the results of MTT assay, the nanoparticles via Ginger rhizome extract led to the death of parasite cells. The IC50 of nanoparticles via Ginger rhizome extract were determined as 16.8 ppm according to MTT assay. High concentrations of nanoparticles led to the destruction of macrophages so that 7.5 % of the cells killed at 40 ppm concentration of nanoparticles.
Regarding the above results, it can be concluded that silver nanoparticles via Ginger rhizome extract has a fatality effect on L. infantum promastigotes in vitro.
Leishmania infantum; Ginger rhizome; in-vitro
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