Effects of silver nanoparticles via ginger rhizome extract on Leishmania infantum: An in-vitro study

Amir KarimiPourSaryazdi ©, Fatemeh Ghaffarifar, Abdolhossein Dalimi, Roya Omidi , Zeinab Moghadamizad

Effects of silver nanoparticles via ginger rhizome extract on Leishmania infantum: An in-vitro study

کد: G-30718

نویسندگان: Amir KarimiPourSaryazdi ©, Fatemeh Ghaffarifar, Abdolhossein Dalimi, Roya Omidi , Zeinab Moghadamizad

زمان بندی: زمان بندی نشده!

برچسب: انگل شناسی پزشکی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Leishmaniasis is a parasitic infection that is more common in the tropical and subtropical regions. According to the World Health Organization report, leishmaniasis is considered as a major global health issue in more continents. The current study was aimed to evaluate the effect of silver nanoparticles via Ginger rhizome extract on Leishmania infantum in-vitro.

Methods

Different concentrations of silver nanoparticles via Ginger rhizome extract promastigotes were investigated. We used promastigote assay and MTT methods to evaluate the toxicity and lethal effects of nanoparticles on L. infantum promastigotes. Also, lethal effects of nanoparticles were tested for macrophage cell with MTT assay.

Results

At high concentrations, nanoparticles had a more lethal effect on parasites. According to the results of MTT assay, the nanoparticles via Ginger rhizome extract led to the death of parasite cells. The IC50 of nanoparticles via Ginger rhizome extract were determined as 16.8 ppm according to MTT assay. High concentrations of nanoparticles led to the destruction of macrophages so that 7.5 % of the cells killed at 40 ppm concentration of nanoparticles.

Conclusion

Regarding the above results, it can be concluded that silver nanoparticles via Ginger rhizome extract has a fatality effect on L. infantum promastigotes in vitro.

Keywords

Leishmania infantum; Ginger rhizome; in-vitro

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