Gut-brain axis modulation with lactobacillus acidophilus: a novel therapy in animal model of Autism
نویسندگان: Amir Masoud Jafari-Nozad, Amirsajad Jafari, Sahar Asadolahizoj, Mohammadreza Hajinezhad ©, Majid Alipour-Eskandani
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فیزیولوژی و فارماکولوژی
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Background and Aim
Autism Spectrum Disorder (ASD) is recognized by difficulties with social interaction along with restricted and repetitive behaviors. influences of microbiome on brain development and behavior is called microbiome-gut-brain axis. Gut microbiota has shown alternations in ASD patients and their mothers. Modulation of gut microbiota with probiotic administration is very renowned in treatment and improvement of diseases. The aim of our study was to investigate serum biochemical parameters, anatomical and behavioral changes in animal model of autism and estimating the effects of different doses of lactobacillus acidophilus, as a probiotic therapy, on the forenamed parameters
Lactobacillus acidophilus was cultured daily and was administered orally at low and high doses to adult female rats, which had received Valproic acid on 12.5 prenatal day, from first day of pregnancy until post-natal day 25 to measure the effects of probiotic on improvement of autistic abnormalities in their offspring. After 50 days of administration, the rats were weaned and behavioral, biochemical and anatomical tests were performed and compared with control groups.
Significant behavioral, biochemical, and anatomical improvements were observed in autistic litters of probiotic receiving dams with high doses during pregnancy and lactation periods in comparison to the control group.
Probiotic administration may be considered as an attenuating or therapeutic factor for autistic patients.
Autism; Valproic acid; Probiotics; Lactobacillus acidophilus
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