Investigating the Correlation between HbA1c, Dyslipidemia and liver Enzymes in Healthy, prediabetic, Diabetic and Uncontrolled diabetic Individuals
نویسندگان: Elham Shakerian ©, Reza Afarin
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Background and Aim
Diabetes mellitus (DM) characterized by chronic hyperglycemia, contributes to a high risk ofmetabolic disorders. Glycemic hemoglobin (HbA1c) reflects average plasma glucose over the previous 8– 12 weeks. The liver plays an important role in maintaining glucose homeostasis. We investigated the relationship between HbA1c, serum lipid profiles, and liver enzymes in healthy, pre-diabetic, diabetic, and uncontrolled diabetic individuals.
Thirty hundred controls with HbA1c lower than 5.7%, 300 prediabetics (HbA1c from 5.7 to 6.4%), 300 types 2 diabetic (HbA1c >6.5% and 300 uncontrolled diabetics (HbA1c >8%), were studied The sera were analyzed for (FBS), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TGs) alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), γ- glutamyltransferase (GGT), Then were analyzed by SPSS.
our study showed that there were significantly lower levels of HDL and Significantly higher levels of TC, TG, LDL, FBS, GGT, and ALT in diabetic and uncontrolled diabetics compared to healthy and prediabetic individuals.
Our results indicated significant increases in lipid parameters, ALT, GGT with increasing HbA1c in diabetic and uncontrolled diabetic, so HbA1c can be used as a good parameter for predicting dyslipidemia. Diabetic patients should do routine monitoring of blood glucose and serum lipid profiles because controlling blood sugar at early stages can reduce the risk of metabolic diseases.
Keywords: Diabetes mellitus; HbA1c; serum lipid profiles; dyslipidemia; liver enzymes
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