Oxidative stress and Animal model of Autism: Is there a link?

Amir Masoud Jafari-Nozad, Amirsajad Jafari, Sahar Asadolahizoj, Mohammadreza Hajinezhad ©, Majid Alipour-Eskandani

Oxidative stress and Animal model of Autism: Is there a link?

کد: G-80197

نویسندگان: Amir Masoud Jafari-Nozad, Amirsajad Jafari, Sahar Asadolahizoj, Mohammadreza Hajinezhad ©, Majid Alipour-Eskandani

زمان بندی: زمان بندی نشده!

برچسب: فیزیولوژی و فارماکولوژی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

Autism spectrum disorder (ASD) is characterized by impaired social interactions as well as stereotype sensory–motor behaviors. The valproic acid (VPA) animal model of autism is one of the most broadly used animal models in terms of simulating ASD symptoms. Intraperitoneal injection of valproic acid on day 12.5 of gestation in rats will cause autism-like symptoms in newborns. The aim of this study was to investigate oxidative stress profile in animal model of Autism.

Methods

pregnant rats were divided equally into control and treatment groups. On day 12.5 of conception, the treatment group received 600 mg/kg valproic acid (dissolved in saline at a concentration of 250 mg/ml) while the control group received normal saline. After weaning of newborns (20 rats), sera samples were isolated. As indicators of oxidative stress, Superoxide dismutase (SOD), Catalase (CAT) and Malondialdehyde (MDA) levels in sera samples were evaluated in both groups using commercial kits

Results

The results of the present study revealed that serum levels of SOD and CAT is significantly lower in VPA group whereas MDA level is higher.

Conclusion

The results of the present study revealed that serum levels of SOD and CAT is significantly lower in VPA group whereas MDA level is higher.

Keywords

Autism; Animal Model; Oxidative Stress

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