The relationship between Helicobacter pylori infection and immunological indicators of TNF-α, CRP, and fibrinogen of patients in the West of Tehran
نویسندگان: Taher Mohammadian ©, Saedeh Chazani Sharahi, Mansoreh Paknejadi
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Background and Aim
Helicobacter pylori infection is the most prevalent infection of the world. There is little information about the possible role of Helicobacter pylori infection on serum levels Tumor necrosis factor- alpha (TNF-α), a cellular cytokine that is classified as a cell-signaling protein, Reactive protein C (CRP), an inflammatory marker, and fibrinogen, a acute phase reactant. This study evaluated the seroprevalence of H. pylori infection on serum levels of TNF-α, CRP and fibrinogen in patients referred to a laboratory in the west of Tehran province.
In this cross-sectional study of the blood of 50 people who referred to clinical lab in the West of Tehran were collected. The titer of total IgG of Helicobacter pylori was evaluated by anti-Helicobacter pylori kit (IgG). Then people with consistently positive or negative results were selected to participate age, sex were recorded. In addition, the determination of serum concentration of total TNF-α was done by ELISA technique. In order to determine the quality of CRP in the serum of the subjects, agglutination method was used. Finally, In order to quantify the amount of fibrinogen in the plasma of the subject, the coagulation method (GLAUSS kit) was used. Date and different results were analyzed by SPSS statistical software.
The Results showed that among the three conditions studied for Helicobacter pylori infection; 32% of the subjects were positive, 54% of the subjects were negative and 14% of the subjects were in the intermediate position and among them, the number of patients was higher in women than men. The serum levels of TNF-α, of CRP and fibrinogen were normal level in volunteers
The results also showed that there is no significant relationship between TNF-α, CRP, Fibrinogen levels in patients and Helicobacter pylori infection. Further studies are necessary for the detection of action mechanism of H. pylori on proinflamatory factors
Helicobacter pylori; proinflamatory factors; prevalence
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