Detection of Epstein–Barr Virus in among women breast cancer in Tabriz

Mahin Ahangar Oskouee ©, Arezou Azadi, Rana Farzi, Farbod Alinezhd, Siamak Tamiri Oskouee

Detection of Epstein–Barr Virus in among women breast cancer in Tabriz

کد: G-48012

نویسندگان: Mahin Ahangar Oskouee ©, Arezou Azadi, Rana Farzi, Farbod Alinezhd, Siamak Tamiri Oskouee

زمان بندی: زمان بندی نشده!

برچسب: ویروس شناسی پزشکی

دانلود: دانلود پوستر

خلاصه مقاله:

Background and Aim

After cervical cancer, breast cancer is the most common type of cancer among women. The cause of this cancer has not yet been fully identified, and several factors, including various environmental factors, including infectious agents, may play a role.. The role of viruses in breast cancer has not yet been well established, however, studies of the association and the presence of EBV in breast cancer, have had inconsistent, from 0% to 50%. The aim of this study, was investigating the EBV EBER gene in paraffin sample women with and without breast cancer in Tabriz.

Methods

In our study, we collected 80 paraffin-embedded malignant breast cancer tissue samples and 80 samples with non-cancerous tissues from the pathology lab in Tabriz. Deparaffinization and DNA extraction was performed using protocol mentioned in previous studies . The EBER region of the EBV genome was used as the primer for the detection of EBV in all samples by PCR .

Results

In our study, EBER gene of EBV was detected in 11.2% (9 out of 80) of breast cancer tissues and none in the non-cancerous tissues. The highest frequency of EBV – EBER in breast cancer samples was observed in Invasive Ductal Carcinoma II (10.9%) and in ≤ 50 age group (13.2%).

Conclusion

Basie of our finding, our results showed a possible role of EBV infection in breast cancer in Tabriz. These patients probably are infected with EBV at an early age, that the virus remains in their bodies, and that it may have contributed to cancer progression so However the controversy remains. Additionally, the exact mechanism of the potential role of EBV in breast cancer is yet to be elucidated.

Keywords

EBV; Breast cancer; Invasive Ductal Carcinoma II

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